Diffusion of Cortexin and Retinalamin in eye sclera

Spectral measurements of sclera reflectance during its interaction with aqueous solutions of both Cortexin and Retinalamin have been carried out. Twenty three samples included in the study were human sclera and rabbit sclera in vitro. The results of the experiments have shown that penetration of Cortexin as well as Retinalamin into sclera tissue leads to the decrease of sclera reflection due to optical immersion. Estimation of diffusion coefficients of studied solutions was made on the basis of analysis of reflectance change dynamics of the sclera samples. Diffusion coefficients of Cortexin and Retinalamin in sclera tissue were estimated as ( ) 6 4.4 2.7 10 ± × and ( ) 6 1.82 0.14 10 ± × cm/sec, respectively. Obtained values of diffusion coefficient allowed estimating time needed for total penetration of both agents through scleral membrane at subtenon's injection of studied agents. The results are important for treatment of partial optic atrophy observed at primary open-angle glaucoma and others eye diseases.